Sero-prevalence and trend of human immunodeficiency virus among blood donors in Ethiopia: A systematic review and meta-analysis.

Henok Mulugeta*¹, Getenet Dessie², Fasil Wagnew¹, Dube Jara³, Cheru Tesema leshargie ⁴, Ayenew Negesse⁵

Abstract
Background: Blood transfusion is one of the routine therapeutic interventions in the hospital that can save the life of a patient. However, there is a risk of several transfusion transmissible infections. Human immunodeficiency virus is one of the major public health problems associated with blood transfusion that affects the safety of blood for the recipient. The objective of this systematic review and meta-analysis is to estimate the pooled sero-prevalence and trend of immunodeficiency virus among blood donors in Ethiopia.

Methods: Studies on the prevalence of human immunodeficiency virus among blood donors were accessed through search from PubMed, Cochrane Library, Google Scholar, EMBASE and CINAHL databases published from 2000 to 2017 with keywords: "Sero-prevalence" AND "trend" AND "HIV" OR "human" AND "immunodeficiency" AND "virus" OR "human immunodeficiency virus" AND "blood donors" OR "blood donors" OR "Ethiopia". Qualities of each article were assessed by using a modified version of the Newcastle-Ottawa Scale. All statistical analyses were done using STATA version 12 software.

Results: The overall estimated pooled sero-prevalence of Human immunodeficiency virus among blood donors in Ethiopia was 2.69% (95% CI (1.79% - 3.58%)). The overall sero-prevalence of human immunodeficiency virus infection shows a significant declining trend from 2000 to 2017.

Conclusion: The analysis showed that the overall sero- prevalence of Human immunodeficiency virus among blood donors in Ethiopia was high. Therefore, routine screening of donor blood for transfusion-transmissible infections is essential for blood transfusion safety.

Keywords: Blood donor, Human immunodeficiency virus, Sero-prevalence, Ethiopia.